Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus
Identifieur interne : 002B25 ( Main/Exploration ); précédent : 002B24; suivant : 002B26Stress as a predictor of symptomatic genital herpes virus recurrence in women with human immunodeficiency virus
Auteurs : Deidre Byrnes Pereira [États-Unis] ; Michael H. Antoni [États-Unis] ; Aimee Danielson [États-Unis] ; Trudi Simon [États-Unis] ; Jonell Efantis-Potter [États-Unis] ; Charles S. Carver [États-Unis] ; Ron E. F. Duran [États-Unis] ; Gail Ironson [États-Unis] ; Nancy Klimas [États-Unis] ; Mary Ann Fletcher [États-Unis] ; Mary Jo O'Sullivan [États-Unis]Source :
- Journal of psychosomatic research [ 0022-3999 ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Maladie, Maladie sexuellement transmissible, Homme.
English descriptors
- KwdEn :
Abstract
Objective: Genital herpes (Herpes Simplex Virus Type 2, HSV-2) is a significant public health problem for HIV+ women, who have high rates of HSV-2 seropositivity and elevated risk for HSV-2 associated morbidity and mortality. Life stress has been identified as a co-factor in genital herpes recurrence. However, no research has evaluated the relationship between stress and genital herpes recurrences in HIV+ women. The purpose of this study was to determine whether stress was associated with symptomatic genital herpes recurrences in women seropositive for HIV and HSV-2, Methods: Thirty-four HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw and gynecologic examination to assess gynecologic symptoms (including genital herpes) at study entry. Life stress was measured using a 10-item modified version of the Life Experiences Survey (LES). Genital herpes recurrence over 1-year follow-up was abstracted using medical chart review. Results: Using hierarchical linear regression analysis, life stress at study entry was significantly associated with number of genital herpes recurrences during 1-year follow-up (β=.38, P=.03) after controlling for HIV disease variables and relevant behavioral factors. Recent life stress, in particular, was highly predictive of genital herpes recurrence during follow-up (β =.57, P =.002). The relationship between life stress and genital herpes recurrence persisted after controlling for HSV-2 viral reactivation (i.e., HSV-2 IgG titers) at study entry. Conclusion: These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV.
Affiliations:
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<term>Comparative study</term>
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<term>Sexually transmitted disease</term>
<term>Somatic disease</term>
<term>Stress</term>
<term>Symptomatology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>SIDA</term>
<term>Maladie</term>
<term>Facteur risque</term>
<term>Maladie sexuellement transmissible</term>
<term>Herpesvirus hominis 2</term>
<term>Symptomatologie</term>
<term>Récidivant</term>
<term>Etude comparative</term>
<term>Prévalence</term>
<term>Stress</term>
<term>Evénement existentiel</term>
<term>Etude longitudinale</term>
<term>Facteur prédictif</term>
<term>Femelle</term>
<term>Homme</term>
<term>Maladie somatique</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie</term>
<term>Maladie sexuellement transmissible</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: Genital herpes (Herpes Simplex Virus Type 2, HSV-2) is a significant public health problem for HIV+ women, who have high rates of HSV-2 seropositivity and elevated risk for HSV-2 associated morbidity and mortality. Life stress has been identified as a co-factor in genital herpes recurrence. However, no research has evaluated the relationship between stress and genital herpes recurrences in HIV<sup>+</sup>
women. The purpose of this study was to determine whether stress was associated with symptomatic genital herpes recurrences in women seropositive for HIV and HSV-2, Methods: Thirty-four HIV-infected African-American and Caribbean-American women underwent a psychosocial interview, blood draw and gynecologic examination to assess gynecologic symptoms (including genital herpes) at study entry. Life stress was measured using a 10-item modified version of the Life Experiences Survey (LES). Genital herpes recurrence over 1-year follow-up was abstracted using medical chart review. Results: Using hierarchical linear regression analysis, life stress at study entry was significantly associated with number of genital herpes recurrences during 1-year follow-up (β=.38, P=.03) after controlling for HIV disease variables and relevant behavioral factors. Recent life stress, in particular, was highly predictive of genital herpes recurrence during follow-up (β =.57, P =.002). The relationship between life stress and genital herpes recurrence persisted after controlling for HSV-2 viral reactivation (i.e., HSV-2 IgG titers) at study entry. Conclusion: These findings suggest that stress may be a significant predictor of genital herpes recurrence in women with HIV and HSV-2. Stress management interventions may buffer HSV-related morbidity and mortality in women with HIV.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Floride</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Floride"><name sortKey="Pereira, Deidre Byrnes" sort="Pereira, Deidre Byrnes" uniqKey="Pereira D" first="Deidre Byrnes" last="Pereira">Deidre Byrnes Pereira</name>
</region>
<name sortKey="Antoni, Michael H" sort="Antoni, Michael H" uniqKey="Antoni M" first="Michael H." last="Antoni">Michael H. Antoni</name>
<name sortKey="Antoni, Michael H" sort="Antoni, Michael H" uniqKey="Antoni M" first="Michael H." last="Antoni">Michael H. Antoni</name>
<name sortKey="Carver, Charles S" sort="Carver, Charles S" uniqKey="Carver C" first="Charles S." last="Carver">Charles S. Carver</name>
<name sortKey="Danielson, Aimee" sort="Danielson, Aimee" uniqKey="Danielson A" first="Aimee" last="Danielson">Aimee Danielson</name>
<name sortKey="Duran, Ron E F" sort="Duran, Ron E F" uniqKey="Duran R" first="Ron E. F." last="Duran">Ron E. F. Duran</name>
<name sortKey="Efantis Potter, Jonell" sort="Efantis Potter, Jonell" uniqKey="Efantis Potter J" first="Jonell" last="Efantis-Potter">Jonell Efantis-Potter</name>
<name sortKey="Fletcher, Mary Ann" sort="Fletcher, Mary Ann" uniqKey="Fletcher M" first="Mary Ann" last="Fletcher">Mary Ann Fletcher</name>
<name sortKey="Ironson, Gail" sort="Ironson, Gail" uniqKey="Ironson G" first="Gail" last="Ironson">Gail Ironson</name>
<name sortKey="Ironson, Gail" sort="Ironson, Gail" uniqKey="Ironson G" first="Gail" last="Ironson">Gail Ironson</name>
<name sortKey="Klimas, Nancy" sort="Klimas, Nancy" uniqKey="Klimas N" first="Nancy" last="Klimas">Nancy Klimas</name>
<name sortKey="Klimas, Nancy" sort="Klimas, Nancy" uniqKey="Klimas N" first="Nancy" last="Klimas">Nancy Klimas</name>
<name sortKey="O Sullivan, Mary Jo" sort="O Sullivan, Mary Jo" uniqKey="O Sullivan M" first="Mary Jo" last="O'Sullivan">Mary Jo O'Sullivan</name>
<name sortKey="Pereira, Deidre Byrnes" sort="Pereira, Deidre Byrnes" uniqKey="Pereira D" first="Deidre Byrnes" last="Pereira">Deidre Byrnes Pereira</name>
<name sortKey="Simon, Trudi" sort="Simon, Trudi" uniqKey="Simon T" first="Trudi" last="Simon">Trudi Simon</name>
</country>
</tree>
</affiliations>
</record>
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